Micro-organisme pour la production sélective d'une composante spécifique d'avermectine et méthode pour cette production sélective

A microorganism for selective production of a specific component of avermectin and a method for selective production thereof

Mikroorganismus zur selektiven Herstellung einer spezifischen Komponente von Avermectin und Verfahren zu deren selektiven Herstellung

Abstract

1. A microorganism of the genus Streptomyces which is capable of selectively producing a specific component of avermectin, said microorganism having one or more of the following properties: specific accumulation of avermectin component "a", effective incorporation of isoleucine or the keto acid thereof (3-methyl-2-oxovaleric acid) into an avermectin molecule, and markedly suppressed incorporation of valine or the keto acid thereof (2-oxoisovaleric acid) into an avermectin molecule.

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Cited By (10)

    Publication numberPublication dateAssigneeTitle
    EP-0572056-A1December 01, 1993Gnosis Srl, EURORESEARCH S.r.L.Aktive Komponente auf der Basis von Avermectinen, verwandter Stamm und Verfahren zu seiner Herstellung sowie diese Komponente enthaltende veterinärmedizinische Zusammensetzung
    EP-0600656-A2June 08, 1994Eli Lilly And CompanyStreptomyces-Stamm für die Herstellung von antiparasitären Verbindungen und Verfahren zu ihrer Anwendung
    EP-0600656-A3July 05, 1995Lilly Co EliSouche de streptomyces pour la production de composés antiparasitaires et procédés les utilisant.
    EP-1160325-A1December 05, 2001The Kitasato InstituteGenes de la synthase d'avermectine aglycone
    EP-1160325-A4June 30, 2004Kitasato InstAvermectin aglycon synthase genes
    US-5376678-ADecember 27, 1994Gnosis Srl, Euroresearch SrlActive principle based on avermectins, related strain and process for the preparation thereof, as well as veterinary compositions containing it
    US-6103504-AAugust 15, 2000Pfizer Inc.Process for production of avermectins and cultures therefor
    US-6864073-B1March 08, 2005The Kitasato InstituteAvermectin aglycon synthase genes
    US-7371548-B2May 13, 2008The Kitasato InstituteAvermectin aglycon synthase genes
    WO-9319194-A1September 30, 1993Pfizer Inc.Procedes de production et de culture d'avermectines